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Just over 18 months after making its video debut, the Navy's electromagnetic railgun has a manufacturer. BAE Systems -- known for e-ink-powered tank camouflage, autonomous spiderbots and machine-gun-mounted lasers -- won the government contract and hopes to have phase-two prototypes ready "as early as next year." While the current design is capable of firing one shot, the Office of Navy Research hopes for six to ten shots per minute. If that doesn't scare you, consider this: The pulse-driven projectiles travel at Mach 6 and can hit targets over 100 nautical miles away. Don't worry, it's not too late to rethink that career of sailing the high seas as a pirate and get to work on that accounting degree instead.
Filed under: Science
Via: Defense Tech
Source: BAE Systems
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Plain white socks these are not. The Atlas sock is a performance dress sock made from cotton, polyester and carbonized coffee. Carbonized coffee? Yes, it helps filter and absorb sweat and odor. Even more, the sock uses strain analysis, pressure mapping and thermal imaging to create something ridiculously comfortable.
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July 2, 2013 ? New research results from Uppsala University, Sweden, show that the key to treating neurodegenerative prion diseases such as mad cow disease and Creutzfeldt-Jakob disease may lie in the ribosome, the protein synthesis machinery of the cell. The results were recently published in the Journal of Biological Chemistry.
Prion diseases are fatal neurodegenerative diseases caused by misfolding of prion proteins. Examples of prion diseases are scrapie in sheep, mad cow disease and Creutzfeldt-Jakob disease in human.
What triggers misfolding of the prion proteins to the amyloid disease form is an open question. The inadequate knowledge in the field about the factors involved in prion formation makes the discovery of effective medicines for prion diseases rather challenging.
"We have now shown that the protein folding activity of the ribosome (PFAR) is most likely involved in prion propagation and thus, can be a specific target for antiprion medicines. If we understand the mechanism fully, we will be able to find ways to stop that too.," says Suparna Sanyal, senior lecturer at the Department of Cell and Molecular Biology, Uppsala University .
The ribosome is the protein synthesis machinery of the cell. The mechanism of protein synthesis by the ribosome is well characterized, while PFAR is a rather recent discovery. PFAR is a ribosomal RNA dependent function of the large subunit of the ribosome irrespective of its source. The PFAR center closely overlaps the peptidyl transferase center although the nucleobases responsible for these two functions are not all common.
"Our results show that two prion inhibitors 6-aminophenanthridine and guanabenz acetate implement antiprion activity by binding to ribosomal RNA and inhibiting PFAR. Thus, the ribosome and more specifically PFAR is the new target for antiprion medicines. Furthermore, we have developed an in vitro PFAR assay, which can be used as a platform for screening prion inhibitors in a high-throughput fashion. This assay is much more time and cost-effective than standard prion assays," says Suparna Sanyal.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/Rj_jDfOp4cM/130702100120.htm
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