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Just over 18 months after making its video debut, the Navy's electromagnetic railgun has a manufacturer. BAE Systems -- known for e-ink-powered tank camouflage, autonomous spiderbots and machine-gun-mounted lasers -- won the government contract and hopes to have phase-two prototypes ready "as early as next year." While the current design is capable of firing one shot, the Office of Navy Research hopes for six to ten shots per minute. If that doesn't scare you, consider this: The pulse-driven projectiles travel at Mach 6 and can hit targets over 100 nautical miles away. Don't worry, it's not too late to rethink that career of sailing the high seas as a pirate and get to work on that accounting degree instead.
Filed under: Science
Via: Defense Tech
Source: BAE Systems
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Plain white socks these are not. The Atlas sock is a performance dress sock made from cotton, polyester and carbonized coffee. Carbonized coffee? Yes, it helps filter and absorb sweat and odor. Even more, the sock uses strain analysis, pressure mapping and thermal imaging to create something ridiculously comfortable.
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July 2, 2013 ? New research results from Uppsala University, Sweden, show that the key to treating neurodegenerative prion diseases such as mad cow disease and Creutzfeldt-Jakob disease may lie in the ribosome, the protein synthesis machinery of the cell. The results were recently published in the Journal of Biological Chemistry.
Prion diseases are fatal neurodegenerative diseases caused by misfolding of prion proteins. Examples of prion diseases are scrapie in sheep, mad cow disease and Creutzfeldt-Jakob disease in human.
What triggers misfolding of the prion proteins to the amyloid disease form is an open question. The inadequate knowledge in the field about the factors involved in prion formation makes the discovery of effective medicines for prion diseases rather challenging.
"We have now shown that the protein folding activity of the ribosome (PFAR) is most likely involved in prion propagation and thus, can be a specific target for antiprion medicines. If we understand the mechanism fully, we will be able to find ways to stop that too.," says Suparna Sanyal, senior lecturer at the Department of Cell and Molecular Biology, Uppsala University .
The ribosome is the protein synthesis machinery of the cell. The mechanism of protein synthesis by the ribosome is well characterized, while PFAR is a rather recent discovery. PFAR is a ribosomal RNA dependent function of the large subunit of the ribosome irrespective of its source. The PFAR center closely overlaps the peptidyl transferase center although the nucleobases responsible for these two functions are not all common.
"Our results show that two prion inhibitors 6-aminophenanthridine and guanabenz acetate implement antiprion activity by binding to ribosomal RNA and inhibiting PFAR. Thus, the ribosome and more specifically PFAR is the new target for antiprion medicines. Furthermore, we have developed an in vitro PFAR assay, which can be used as a platform for screening prion inhibitors in a high-throughput fashion. This assay is much more time and cost-effective than standard prion assays," says Suparna Sanyal.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/Rj_jDfOp4cM/130702100120.htm
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PRETORIA, South Africa (AP) ? The spelling and grammar need work, but the message has its own eloquence.
A 10-year-old's note to Nelson Mandela, the prisoner who fought South African apartheid, or white racist rule, and became a global emblem of unity and humility, addresses him as "the greates president are land has ever had it is realy bad that you are in the hospital. But realy cool that you stopt apartit. you maid are land A beter place"
It is one of hundreds of messages that have been placed at two makeshift shrines by South Africans and others who are celebrating the life and legacy of Mandela, 94, even as some openly lament that his life may be approaching an end.
The South African government said Monday that Mandela remains in "critical but stable" condition in the hospital where he was admitted on June 8.
The hospital in downtown Pretoria is one of those pilgrimage sites; the other is his home in Houghton, a tree-lined neighborhood in Johannesburg where high walls ring expansive homes.
A swell of well-wishers has deposited letters, paintings, candles, stuffed bears and bouquets of flowers outside these spots, reflecting the cathartic mood of a nation whose identity is so closely linked to an ailing man who is out of public sight. It is a bittersweet time for South Africa, proud of its power to reconcile amid racial conflict but struggling to fulfill expectations of a better life two decades after the end of apartheid.
The former president is visited daily by his family, and on Monday the three other surviving defendants in the sabotage trial in which Mandela was sentenced to life in prison in 1964 visited the hospital.
Even in this most vulnerable moment, Mandela is again emerging as an enabler, this time for a new generation, across racial and gender lines.
"I am a 16 year old girl who wanted to meet you very much. Unfortunately I did not have the oppurtunity, but even in the early stages of my life I decided that I wanted to be a caring, loving person just like you," writes Carien Struwig, who left her telephone number on a note at the Mediclinic Heart Hospital entrance, perhaps hopeful that she might get summoned inside.
"Ps. I am Afrikaans, sorry for any incorrect spelling or grammar," she writes in English.
Mandela reached out to the Afrikaner community that devised apartheid and jailed him for 27 years, negotiating an end to white minority rule and allaying fears of widespread racial war. Freed in 1990, the anti-apartheid leader was elected president in an all-race vote in 1994, an event that electrified people around the world because of its sense of peaceful promise.
The mood at these impromptu shrines is partly festive and partly mournful, likely a harbinger of the outpouring that will accompany Mandela's inevitable demise. His protracted illness, the final struggle of a momentous life, has become a time for national introspection and a chance for people to be a part of something bigger than themselves.
People pray, hands pressed to faces. Choirs sing and sashay. On Saturday, a group of Pentecostal worshippers stood outside the hospital gates, wailing, shouting and gesturing. A wall of photographers recorded the emotional paroxysm.
An artist displayed a painting of a robust-looking Mandela with a finger on his lips, symbolizing his perceived desire for quiet as he battles a recurring lung infection and other ailments. When President Barack Obama was visiting South Africa this weekend, three men in dark suits and sunglasses, apparently members of the presidential security detail, soaked up the scene at the hospital entrance. One of the men politely declined to speak to an Associated Press reporter, saying he was off-duty and would get in trouble if he spoke to the media.
The sense of occasion is across the country, including Cape Town, where an exhibition about Mandela recently opened in a civic center; in coastal Durban, where a mass prayer session was held; in Qunu, the rural village where Mandela grew up and where he is expected to be buried; and Soweto, the area of Johannesburg where he once lived.
On Soweto's Vilakazi Street, a tourist hub where Mandela's old brick home has been turned into a museum, two rappers sang about Mandela, patting their chests for a beat. Impressionist Peter Bopape imitated Mandela's raspy, deliberately paced voice.
"I decided to come out of the hospital today, just to come and thank all the South Africans and the support that you're showing me," Bopape said in Mandela's stately tones.
Mandela often said many people played a role in making South Africa better. That it was not only his doing, that he made mistakes. But the written tributes to Mandela suggest there is no one like him in the country, and possibly in the world, who can connect with people of all walks at their core.
"Families like ours exist partly because of you!" reads a caption below a photo of two white women and two black children who are seated with a third woman in an apron who appears to be a housekeeper.
One message to Mandela comes from a day care center, another from a group of platinum mine workers.
One writer recalled seeing Mandela raise his fist after being released from prison in Paarl, the writer's hometown.
"My whole life, you'd been in prison, and now you were stepping out, surrounded by the very mountains that held me every day as I grew up," the handwritten note says.
"In 1994 I walked along Pretorius street to the Union Buildings to witness your inauguration. I raised my fist as the helicopters flew over with rainbow nation streaks of smoke trailing behind them. For the first time in my life I felt patriotism and pride in the leader of my country."
Source: http://news.yahoo.com/ailing-mandela-still-able-unite-south-africans-163132901.html
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